Patrick Fickers

The paper enhances succinic acid production in a Yarrowia lipolytica strain lacking succinate dehydrogenase by redirecting metabolic flux and improving NADH availability.

This study enhances AOX1 promoter self-induction in K. phaffii by engineering serine metabolism to increase formate production, improving recombinant protein productivity without methanol.

This study shows that increased sorbitol metabolism reduces AOX1 promoter induction in K. phaffii, while lower oxygen transfer enhances it, affecting recombinant protein productivity.

The paper shows that formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficient Pichia pastoris, enabling self-induced protein expression without methanol.