Author

Rocio Cozmar

Pontificia Universidad Católica de ValparaísoORCID 0009-0000-5862-595XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Julio BerríosiD· 2 shared Patrick FickersiD· 2 shared Cristina BustosiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBioengineering

Julio BerríosORCID

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2 papers

Recent·Most cited

BioengineeringMicrobial Cell FactoriesPeer-reviewedMar 8, 2026

Engineering serine metabolism to enhance AOX1 promoter self-induction in a formate dehydrogenase-deficient Komagataella phaffii

Rocio Cozmar, Julio Berríos, Patrick Fickers

This study enhances AOX1 promoter self-induction in K. phaffii by engineering serine metabolism to increase formate production, improving recombinant protein productivity without methanol.

2 citations

yeastproteomics

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BioengineeringbioRxivPreprintApr 1, 2025

Sorbitol uptake and oxygen transfer shape AOX1 promoter induction under methanol-free conditions in Komagataella phaffii lacking formate dehydrogenase

Cristina Bustos, Rocio Cozmar, Julio Berríos, Patrick Fickers

This study shows that increased sorbitol metabolism reduces AOX1 promoter induction in K. phaffii, while lower oxygen transfer enhances it, affecting recombinant protein productivity.

DOI 10.1101/2025.04.01.646572

yeastbulk RNA-seq

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