Jian Li

The paper reports the cryo-EM structure of TRPC1/5 heterotetramer, revealing structural features that differentiate it from TRPC5 homomers and provide insights into its functional properties.

This study investigates the inhibition of coronaviral main proteases by PF-00835231, showing broad-spectrum activity and providing structural insights into its binding modes.

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

This study presents cryo-EM structures of human cone visual pigments in complex with G proteins, revealing their active state and mutations affecting spectral tuning.

The paper presents the 2.9 angstrom cryo-EM structure of TRPC5, revealing its partially open apo state and structural differences from other TRP channels.