Author
Broad InstituteORCID 0000-0001-9523-2127Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Dharma R. Thapa, Riva Deodhar, Adam P. Skepner…·Srinivas Raghavan Viswanathan
The paper identifies CDK9 inhibition as a therapeutic strategy for translocation renal cell carcinoma through phenotypic screening and mechanistic analysis.
Subrata Shaw, Wei Jiang, Jason S. Rush…·Peter Grant Miller
This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.
Srinivas Niranj Chandrasekaran, Beth A. Cimini, Amy B. Goodale…·Anne Elizabeth Carpenter
The paper introduces a dataset of cell morphology images treated with matched chemical and genetic perturbations and evaluates methods for identifying perturbation similarities.
Beth A. Cimini, Srinivas Niranj Chandrasekaran, Maria Kost‐Alimova…·Anne Elizabeth Carpenter
The paper updates the Cell Painting assay protocol to improve morphological profiling, finding that simplified steps and reduced stain concentrations maintain robust outputs.