Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors
Devin Miles, Daniel Sforza, Nicole Tan, Yanbo Yang, Mina Akter, Xingyu Chen, Chanel Hutchinson, Hawley Helmbrecht, Tyler Findlay, Lingshu Yin, Kan Ota, Masumi Umezawa, Yuncheng Zhong, Curtiland Deville, Matthew Ladra, , Sahaja Acharya
This study shows that synchrotron-based proton FLASH techniques preserve neurocognitive function in mice, with neuroprotection observed across different delivery methods and dose-rate metrics.
bioRxiv · Jun 2, 2026 · PreprintCancer Biology