Author

Dina DeSousa

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Adrian Peter BirdiD· 2 shared Jim SelfridgeiD· 2 shared Beatrice Alexander-HowdeniD· 1 shared Bernard H. Ramsahoye· 1 shared Christian SeiseriD· 1 shared Chuan HeiD· 1 shared Gabriele SchweikertiD· 1 shared Guido SanguinettiiD· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Adrian Peter BirdORCID

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2 papers

Recent·Most cited

A mutation-led search for novel functional domains in MeCP2

Jacky Guy, Beatrice Alexander-Howden, Laura FitzPatrick, Dina DeSousa, Martha V. Koerner, Jim Selfridge, Adrian Peter Bird

The paper investigates the molecular effects of non-canonical MeCP2 mutations in neurons and mice, finding they impact known domains rather than causing new molecular mechanisms of Rett syndrome.

Human Molecular Genetics · Apr 26, 2018Peer-reviewedMolecular Biology

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain

Sabine Lagger, John C. Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H. Ramsahoye, Miao Yu, Dina DeSousa, Christian Seiser, Chuan He, Guido Sanguinetti, Lawrence C. Sowers, Malcolm D. Walkinshaw, Adrian Peter Bird

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.

PLoS Genetics · May 12, 2017Peer-reviewedMolecular Biology