BiochemistrybioRxivPreprint
An isothermal calorimetry assay for determining steady state kinetic and enzyme inhibition parameters for SARS-CoV-2 3CL-protease
Luca Mazzei, Sofia Ranieri, Rebecca Greene-Cramer…·Stefano Ciurli
This paper develops an ITC assay to measure kinetic and inhibition parameters of SARS-CoV-2 3CL-protease, revealing two inhibition modes and deriving kinetic constants with high precision.
DOI 10.1101/2024.01.31.578159