Author

Arne Nedergaard Kousholt

The Netherlands Cancer InstituteORCID 0000-0002-3972-1740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Jos JonkersiD· 2 shared Anne‐Claude GingrasiD· 1 shared Atina G. CotéiD· 1 shared Bas van SteenseliD· 1 shared Christ LeemansiD· 1 shared Daniel DurocheriD· 1 shared Daniel R. TabetiD· 1 shared Dheva SetiaputraiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Jos JonkersORCID

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3 papers

Recent·Most cited

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Ke Cong, Nathan J. MacGilvary, Silviana Lee, Shannon G. MacLeod, Jennifer A. Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A. Day, Sharon B. Cantor

The paper investigates how FANCJ helicase affects PARP1 activity during DNA replication in BRCA1 deficient cells, revealing its role in PARPi efficacy and resistance.

Nature Communications · Mar 23, 2024Peer-reviewedMolecular Biology

Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis

Yichao Zhao, Daniel R. Tabet, Diana Rubio-Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen‐Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne‐Claude Gingras, Fernando Gómez-Herreros, Frederick P. Roth, Daniel Durocher

The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.

bioRxiv · Sep 23, 2022 · PreprintMolecular Biology

Easy quantification of template-directed CRISPR/Cas9 editing

Eva Karina Brinkman, Arne Nedergaard Kousholt, Tim Harmsen, Christ Leemans, Tao Chen, Jos Jonkers, Bas van Steensel

The paper introduces TIDER, a method to quantify template-directed CRISPR/Cas9 editing efficiency using an adapted TIDE approach.

Nucleic Acids Research · Feb 22, 2018Peer-reviewedGenetics