Xiaodong Tian

This paper develops two hybrid calcium indicators, HyBRIC and HyBRIC2, that use luciferase activation and BRET for high-contrast red-window calcium imaging with improved brightness and responsiveness.

The paper introduces hpGRISZ, a fluorescent biosensor for in vivo imaging of synaptic zinc dynamics, showing high responsiveness and suitability for detecting extracellular zinc release.

This study shows that 7-ketocholesterol increases astrocyte oxidative stress in Alzheimer's disease via microglia activation.

This paper develops a bioluminescent indicator for potassium ions using a modified luciferin and engineered luciferase, validated in cell lines, neurons, and live mice.

The paper develops new luciferin substrates that enhance bioluminescence brightness and stability, enabling high-speed video-rate imaging of mice with improved sensitivity and non-invasive monitoring of calcium activity.

This study develops a genetically encoded far-red fluorescent indicator (FRISZ) to image synaptic Zn2+ dynamics in live animals and demonstrates its use in the auditory cortex of awake mice.

This paper develops a bioluminescent calcium indicator and prosubstrate for non-invasive imaging of neuronal activity in awake mice.