Heather Anne Ferris

This study shows that 7-ketocholesterol increases astrocyte oxidative stress in Alzheimer's disease via microglia activation.

The paper shows mechanical force activates TREK-1 channels via PLD2 and lipid clustering, leading to second messenger signaling and ion flow.

This study investigates circadian re-entrainment in Alzheimer's disease mouse models, finding faster re-entrainment in 3xTg and 5xFAD mice, independent of microglia or tau pathology, suggesting altered light sensing contributes to circadian behavior changes.

This study shows that astrocyte-derived cholesterol, released via apoE, promotes neuroinflammation by enhancing inflammatory signaling in immune cells.

The paper identifies SOD1 as a mediator of lysosome-to-mitochondria communication and shows its dysregulation by amyloid-β oligomers in Alzheimer's disease.

The paper shows astrocyte-derived cholesterol regulates amyloid precursor protein trafficking to lipid rafts, affecting Aβ and sAPP production in neurons, and disrupting cholesterol synthesis reduces amyloid pathology in mice.

This study shows that myeloperoxidase from neutrophils in the meninges modulates neuronal function after subarachnoid hemorrhage, leading to cognitive deficits.