Charles R. Midgett

This paper identifies regacin as an inhibitor of RegA, a virulence regulator in Citrobacter rodentium, and defines its binding site through structural and mutagenesis studies.

This study reveals how bile salts induce ToxS homodimerization, providing a structural model for ToxRS system activation in Vibrio pathogens.

This study identifies key residues in the Rns binding pocket critical for fatty acid inhibition and structural rigidity, supporting the hypothesis that fatty acid binding inhibits AraC regulators in bacterial pathogens.

This paper shows that CsrA directly increases ToxR levels in Vibrio cholerae by stabilizing and enhancing translation of toxR mRNA through binding to its 5 UTR.