Kacey Marie Talbot

The small molecule regacin binds a conserved pocket in RegA to inhibit the expression of bacterial virulence factors

This paper identifies regacin as an inhibitor of RegA, a virulence regulator in Citrobacter rodentium, and defines its binding site through structural and mutagenesis studies.

Regulation and Characterization of the Cex system of enteric pathogens: a pathway for the lipidation and secretion of noncanoncial bacterial lipoproteins

This study characterizes the Cex system in enteric pathogens, showing that Rns regulates lipidation and secretion of noncanonical bacterial lipoproteins through a novel acyltransferase, CexD.

Linking the kinetic mechanism to structural dynamics required for nucleotide hydrolysis by an alphavirus nsP2 RNA helicase

This study characterizes the kinetic mechanism and structural dynamics of Chikungunya virus nsP2 RNA helicase during nucleotide hydrolysis using biochemical and computational methods.

Characterization of the ligand binding pocket of the virulence regulator Rns, a Member of the AraC/XylS family of transcription factors

This study identifies key residues in the Rns binding pocket critical for fatty acid inhibition and structural rigidity, supporting the hypothesis that fatty acid binding inhibits AraC regulators in bacterial pathogens.

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.