Stephanie Schaefer‐Ramadan

The paper introduces AVA-Seq, a method using long-read sequencing to detect full-length protein-protein interactions, achieving a 28.6% recovery rate on a gold standard dataset.

The paper identifies novel interactions between the APC protein and Wnt-pathway nuclear transcription factors, suggesting APC may repress CTNNB1 through transcription factor binding.

The paper tests AVA-Seq on a human PPI reference set, finding it recovers 43% of binary PPIs and identifies novel interactions.

This paper introduces AVA-seq, a method using next-generation sequencing to map protein-protein interactions with high resolution, demonstrating its application on human proteins.