Jingping Yang

The paper measures and predicts non-coding variant effects in human immune cells using single-cell ATAC-seq and whole-genome sequencing, revealing regulatory mechanisms and applications in systemic lupus erythematosus.

CellMATE is a method that captures both additive and synergistic benefits of multimodal joint profiling by integrating single-cell and spatial data into a unified latent space.

This study introduces a method to identify causal genes and regulatory mechanisms in hyperuricemia by integrating single-cell data with genetic findings.