Balázs Koscsó

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

This study shows that activating the alpha7 nicotinic receptor in macrophages triggers TFEB nuclear translocation and a pro-inflammatory gene signature without cytokine release.