Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System
Sravya Kurapati, Changsik Shin, Krisztina Szabo, Yu Liu, Azree Zaffran Ashraf, Balázs Koscsó, Chinmayee Priyadarsini Dash, Katherine L. Kruckow, L Guerrero Navarro, Amanda M. Clark, Monalee Saha, Sushma Nagaraj, Wenhui Wang, Jun Zhu, Kevin Brown, , Milena Bogunovic
The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.
The Journal of Experimental Medicine · Dec 20, 2025Peer-reviewedImmunology