Christina E. Baer

Comparative spatial transcriptomics of hair follicle-T cell interactions in mouse, dog and human reveals conserved drivers of primary cicatricial alopecia

This study uses spatial transcriptomics across mouse, dog, and human to identify conserved T cell-hair follicle interactions in PCA, revealing potential drug targets.

Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

Reliable multiplex generation of pooled induced pluripotent stem cells for genetic testing

The paper introduces a method to multiplex reprogram somatic cells into iPSCs and estimates donor contributions using pooled sequencing and SNPs, finding consistent reprogramming ability across donors.

A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature

This paper analyzes juxtavascular microglia dynamics in mice and humans, showing their developmental migration along vessels and stabilization as astrocyte endfeet ensheath the vasculature.

ORBIT: a new paradigm for geneticengineering of mycobacterial chromosomes

ORBIT enables high-throughput chromosomal engineering in mycobacteria without requiring custom double-stranded DNA substrates by combining recombination systems and reusable payload plasmids.