Latasha Little

This study compares imaging-based spatial transcriptomics platforms using FFPE tumor samples, finding differences in performance and highlighting factors affecting data quality.

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

The paper investigates how anti-cancer immunity evolves from preneoplasia to invasive lung adenocarcinomas, identifying changes in immune response and molecular features that may facilitate immune evasion.

This study shows that transcriptomic features, not genomic characteristics, drive the histologic phenotype of lung cancers.

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.