Jianhua Zhang

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

This study identifies diet-induced mitochondrial DNA replication instability in Rad51c mutant mice as a molecular cause of sex-bias in anemia of inflammation, showing estrogen protects females by reducing oxidative stress.

This study identifies distinct microbial subtypes in adenoid cystic carcinomas and links them to patient outcomes and tumor biology.

The paper investigates how anti-cancer immunity evolves from preneoplasia to invasive lung adenocarcinomas, identifying changes in immune response and molecular features that may facilitate immune evasion.

This study examines DNA methylation changes and intra-tumor heterogeneity in lung adenocarcinoma progression, finding increased methylation aberrations and immunosuppression in later-stage lesions.

This study shows that transcriptomic features, not genomic characteristics, drive the histologic phenotype of lung cancers.

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.

The paper develops a network-based approach to identify predictive biomarkers and therapeutic combinations for anti-PD-1 immunotherapy, finding genes and pathways associated with response and validating them through CRISPR and drug target data.