Author

Xiaosai Yao

GenentechORCID 0000-0001-9729-0726Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Bence DánieliD· 2 shared Minyi ShiiD· 2 shared Robert L. YauchiD· 2 shared Aaron T. L. LuniD· 1 shared Adrian Waddell· 1 shared Alden King-Yung LeungiD· 1 shared Alejandro Martinez ChiblyiD· 1 shared Aleksander ChlebowskiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Bence DánielORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedJan 14, 2026

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

Phillip Thienger, Irene Paassen, Xiaosai Yao…·Mark A. Rubin

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

11 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsNature CommunicationsPeer-reviewedAug 2, 2025

Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell state

Tomasz Włodarczyk, Aaron T. L. Lun, Diana H. Wu…·Xiaosai Yao

Epiregulon infers single-cell TF activity using ATAC-seq and RNA-seq to predict drug response and identify drivers of cell state.

13 citations

humanscATAC-seq

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