RUNX1 aberrations in blast-phase CML induce the RBP SPATS2L which promotes growth, survival and stress granule assembly
David A. Palmer, Amy Lianne Muir, R Craig, Philip A. Lewis, Marieangela C. Wilson, Kate J. Heesom, Gillian Abigail Horne, Mhairi Copland, Satu M. Mustjoki, Shady Adnan Awad, Kimmo Porkka, Sanjana Jain, Elif Nehir Bayat, Dennis Famili, Helen Webb, , Rhys G Morgan
This study identifies SPATS2L as a mediator of growth and survival in RUNX1-mutant blast-phase CML through stress granule formation, suggesting it as a therapeutic target.
bioRxiv · Mar 30, 2026 · PreprintCancer Biology