Mechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688
Yan Wang, Long Sun, Luciana de Souza Fernandes, Yu-Hsiu Wang, Jing Zou, Samuel J. Franklin, Yanping Hu, Lee K. Palmer, Jason Yeung, Daniela Barriga, William K. Russell, Stephanie A. Moquin, Pei‐Yong Shi, Colin K. Skepper, Xuping Xie
This study identifies how NITD-688 inhibits dengue virus by binding NS4B and disrupting its interaction with NS3, reducing viral replication.
Proceedings of the National Academy of Sciences · Mar 28, 2025Peer-reviewedMicrobiology