Kyle M. Miller

HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair

This study identifies HELZ as an RNA-DNA helicase that resolves R loops to support homologous recombination repair and genomic stability.

Tracing Cellular Senescence in Bone: Time-Dependent Changes in Osteocyte Cytoskeleton Mechanics and Morphology

This study investigates time-dependent changes in osteocyte cytoskeleton mechanics and morphology due to senescence-associated secretory phenotype factors, identifying biophysical markers for senescent osteocytes.

Identification of Novel Modulators of the ALT Pathway Through a Native FISH-Based Optical Screen

This study identifies novel genes that modulate the ALT pathway using a high-throughput imaging screen, revealing both promoting and inhibiting factors and demonstrating pharmacological modulation potential.

RPS19 and RPL5, the most commonly mutated genes in Diamond Blackfan anemia, impact DNA double-strand break repair

This study shows that RPS19 and RPL5 mutations in DBA impair DNA double-strand break repair, potentially explaining cancer risk in patients.

TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

This study identifies TRIM24's role in ALT telomere maintenance through chromatin signaling, showing it promotes telomere DNA synthesis via SUMO-dependent mechanisms.

Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation

This study identifies the RFTS domain of DNMT1 as a reader for H3K9me3/H3Ub, showing its role in DNA methylation maintenance and genomic stability.

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

This study shows that Sae2/CtIP prevents R-loop accumulation by facilitating their removal, with CtIP nuclease activity playing a critical role in this process.