Decoupling gene knockout effects from gene functions by evolutionary analyses
Li Liu, Mengdi Liu, Di Zhang, Shanjun Deng, Piaopiao Chen, Jing Yang, Yunhan Xie, Xionglei He
The paper shows that gene deletion effects can be split into clustered and distributed effects, with only clustered effects aligning with known biochemical functions and distributed effects being evolutionarily decoupled.
National Science Review · Apr 22, 2020Peer-reviewedGenetics