Piaopiao Chen

This study shows gene expression plasticity in yeast is adaptive under antibiotic stress but neutral under osmotic stress, using mutation accumulation lines to distinguish selection effects.

The paper shows that gene deletion effects can be split into clustered and distributed effects, with only clustered effects aligning with known biochemical functions and distributed effects being evolutionarily decoupled.

The paper identifies type II essential genes, which can become non-essential through secondary loss-of-function mutations, suggesting a therapeutic strategy for human diseases like ADSL deficiency.