Outi K. Hallikas

broadSeq benchmarks differential gene expression methods and shows DELocal identifies distinct genes by considering genomic neighbourhood, particularly for highly expressed genes.

The paper investigates how mammalian molar teeth scale during development and evolution, finding that the IGF pathway regulates both growth and cusp patterning to achieve size differences.

The paper introduces DELocal, an algorithm that uses gene neighbourhood information to detect subtle changes in gene expression during organ development, showing it outperforms traditional methods.

The paper identifies developmental keystone genes in mouse and rat tooth development by analyzing phenotypic severity and gene expression patterns, revealing conserved system-level dynamics.