Satu Kuure

'broadSeq', a benchmarking tool to contrast differential gene expression methods and identify when genomic neighbourhood matters

broadSeq benchmarks differential gene expression methods and shows DELocal identifies distinct genes by considering genomic neighbourhood, particularly for highly expressed genes.

Human models of GLE1 associated LCCS1 reveal neural crest deficiency and multisystem developmental failure accompanied by altered RNA metabolism

This study uses human stem cells and tissues to investigate LCCS1, revealing impaired RNA metabolism and developmental defects in neural crest and neuromuscular systems.

Testosterone exposure during fetal masculinization programming window determines the kidney size in adult mice.

The paper shows that fetal testosterone deficiency reduces adult male kidney size in mice by affecting growth pathways.

Novel Cln8 p.R24G mouse line replicates major clinical features of Northern epilepsy

This paper generates a Cln8 p.R24G mouse model that phenocopies major clinical features of Northern epilepsy, including seizures and neurodegeneration.

GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

This study investigates the role of GLE1 in cellular homeostasis and development, showing that its dysfunction leads to embryonic lethality and mid-adulthood death in mice, with defects in neural crest-derived tissues and stress responses.

Hepatic mitochondrial respiration is crucial for euthermia in complex III-deficient mice with impaired brown adipose tissue thermogenesis

This study shows that restoring mitochondrial complex III function in the liver of CIII-deficient mice prevents hypothermia and improves survival by enabling normal thermoregulation.

Biomechanical regulation of cell shapes promotes branching morphogenesis of the ureteric bud epithelium

This study investigates how biomechanical regulation of cell shapes influences branching morphogenesis in the ureteric bud epithelium, identifying key cellular mechanics involved in branch formation.

FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells

This study shows FGF8 promotes chemokinesis in mouse nephron progenitor cells, facilitating their condensation around ureteric buds.

Exploring the principles of embryonic mammary gland branching morphogenesis

This study investigates branching morphogenesis in the embryonic mammary gland using ex vivo and in vivo techniques, revealing stochastic branching patterns and pathway-dependent regulation.

Omics profiling identifies MAPK/ERK pathway as a gatekeeper of nephron progenitor metabolism

The paper identifies the MAPK/ERK pathway as critical for nephron progenitor metabolism, showing its role in energy and nucleotide biosynthesis, glycolysis, and proline metabolism.

Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF

This study shows that excess fetal GDNF can prolong nephrogenesis in postnatal mouse kidneys without increasing tumor risk.