Ophir D. Klein

The paper shows that tissue tension enables Src-mediated β-catenin phosphorylation, which is critical for mesoderm specification in human embryonic stem cells.

The paper shows the enteric nervous system (ENS) lacks intrinsic regionalization but is shaped by PTPRZ1 signaling from the gut microenvironment during development.

This paper uses 3D facial morphometry to analyze facial shape changes in Cri-du-Chat syndrome and related genetic conditions, identifying genotype-phenotype correlations and critical genomic regions.

This study identifies CNPY4 as a sphingolipid-binding protein that regulates sphingolipid levels and distribution, impacting cholesterol homeostasis and cellular signaling.

This study shows that IL-25 induces memory ILC2s in the small intestine that provide long-term protection against barrier pathogens.

The paper maps mesenchymal diversity in the developing human intestine and organoids using single-cell RNA-sequencing and spatial transcriptomics, identifying distinct fibroblast populations and their spatial organization.

The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.

This study compares univariate phenotyping strategies for 3D facial shape in GWAS, finding that inter-landmark distances and AE-derived dimensions show higher heritability than facial resemblance to gestalts.

The paper identifies genomic loci associated with achondroplasia-like facial variation in the general population using a syndrome-informed phenotyping approach.

The paper identifies EFNA3 as a factor promoting mammary epithelial collective migration and cancer metastasis by enhancing oxidative phosphorylation.

This study shows mammary epithelial migration occurs without EMT, relying on preserved cell-cell adhesion and Snail1's role in directional movement.

This study investigates adult-onset Sprouty1/2/4 triple knockout mice, revealing endocrine defects without increased tumor incidence.

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

The paper identifies five discrete metabolic domains in the mouse and human small intestine using transcriptional signatures and machine learning, showing how diet influences domain properties.

The paper shows that intracellular pH dynamics regulate intestinal stem cell lineage specification by promoting secretory or absorptive differentiation depending on pH levels.

The paper investigates how mammalian molar teeth scale during development and evolution, finding that the IGF pathway regulates both growth and cusp patterning to achieve size differences.

The paper modulates SOX9 levels in human facial progenitors to study dosage sensitivity and identifies regulatory elements and genes that are sensitive to SOX9 changes.

The paper identifies EPIREGULIN as a niche factor that enables spatial organization in human intestinal organoids, mimicking the native intestine's structure and gene expression.

MusMorph provides standardized mouse morphology data for meta-analyses, including craniofacial and brain structures across developmental stages and genotypes.

This study evaluates the Full Genome Analysis method for diagnosing rare monogenic disorders, finding a 40% diagnostic yield in clinical cases.

This study shows that SOX2, regulated by Hedgehog signaling, is essential for maintaining adult lingual epithelium homeostasis, including taste bud differentiation and epithelial cell balance.

This study shows that two distinct progenitor populations in salivary glands maintain ductal architecture after radiation damage through different mechanisms.