Jukka Jernvall

'broadSeq', a benchmarking tool to contrast differential gene expression methods and identify when genomic neighbourhood matters

broadSeq benchmarks differential gene expression methods and shows DELocal identifies distinct genes by considering genomic neighbourhood, particularly for highly expressed genes.

Contemporary hybridization and localized genomic differentiation between grey seal subspecies

The paper uses whole-genome sequencing to study hybridization and genomic differentiation between grey seal subspecies in a contact zone, finding evidence of recent hybridization and local adaptation.

Deep origins and distinct adaptations indicated for a glacial relict seal

The paper shows Saimaa ringed seals originated 60,000 years ago, long before their lake habitat formed, and have distinct adaptive traits.

Realisation threshold revisited: does the minimum tooth size scale with body size?

This study investigates whether the minimum tooth size (realisation threshold) scales with body size by comparing variably present teeth across mammals, finding they are relatively small in large mammals but larger than the theoretical minimum.

On growth and form of the mammary gland: Mesenchyme instructs growth while epithelium directs branching

This study shows that mammary epithelium dictates branching patterns while mesenchyme controls growth and density during mammary gland development.

Wnt target gene Ascl4 is dispensable for skin appendage development

This study shows that Ascl4, a Wnt/{beta}-catenin target gene, is not essential for skin appendage development in mice.

The developmental basis for scaling of mammalian tooth size

The paper investigates how mammalian molar teeth scale during development and evolution, finding that the IGF pathway regulates both growth and cusp patterning to achieve size differences.

Gene Expression Detection in Developing Mouse Tissue Using In Situ Hybridization and microCT Imaging

The paper introduces GECT, a method combining in situ hybridization with microCT to detect gene expression in developing mouse tissues, showing compatibility with existing imaging techniques.

Transcriptomic landscape of early hair follicle and epidermal development

The paper uses bulk and single-cell transcriptomics to study early hair follicle and epidermal development, identifying new cell populations and markers.

Chromosomal neighbourhoods allow identification of organ specific changes in gene expression

The paper introduces DELocal, an algorithm that uses gene neighbourhood information to detect subtle changes in gene expression during organ development, showing it outperforms traditional methods.

System-level analyses of keystone genes required for mammalian tooth development

The paper identifies developmental keystone genes in mouse and rat tooth development by analyzing phenotypic severity and gene expression patterns, revealing conserved system-level dynamics.