Author

Ya Yin Chang

UK Dementia Research InstituteORCID 0000-0001-9794-403XUnclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Calum BonthroniD· 1 shared Claire S. DurrantiD· 1 shared Danilo NegroiD· 1 shared Declan KingiD· 1 shared Francesco GobboiD· 1 shared Imran Liaquat· 1 shared James H. CattersoniD· 1 shared Jamie ElliottiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Calum BonthronORCID

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1 paper

Recent·Most cited

Opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Robert I. McGeachan, Soraya Meftah, Lewis W. Taylor, James H. Catterson, Danilo Negro, Calum Bonthron, Kristján Holt, Jane Tulloch, Jamie L. Rose, Francesco Gobbo, Ya Yin Chang, Jamie Elliott, Lauren McLay, Declan King, Imran Liaquat, , Claire S. Durrant

This study uses live human brain slice cultures to show that physiological and pathological amyloid-beta have opposing effects on synapses, with physiological levels enhancing synaptic transcripts and pathological levels causing synaptic loss.

Nature Communications · Apr 30, 2025Peer-reviewedNeuroscience