Author

Kristján Holt

UK Dementia Research InstituteORCID 0000-0003-3903-6361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Tara L. Spires‐JonesiD· 4 shared Claire S. DurrantiD· 3 shared Declan KingiD· 3 shared James H. CattersoniD· 3 shared Jamie L. RoseiD· 3 shared Jane TullochiD· 3 shared Robert I. McGeachaniD· 3 shared Soraya MeftahiD· 3 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Tara L. Spires‐JonesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedApr 30, 2025

Opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Robert I. McGeachan, Soraya Meftah, Lewis W. Taylor…·Claire S. Durrant

This study uses live human brain slice cultures to show that physiological and pathological amyloid-beta have opposing effects on synapses, with physiological levels enhancing synaptic transcripts and pathological levels causing synaptic loss.

23 citationstop 1%

humanexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 6, 2024

Microglia determine beta-amyloid plaque burden but are non-essential for downstream pathology

Mosi Li, Kristján Holt, Katherine Ridley…·Giles E. Hardingham

This study shows microglia promote beta-amyloid plaque formation but are not required for subsequent pathological changes in Alzheimer's disease.

2 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceActa NeuropathologicaPeer-reviewedFeb 6, 2024

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease

Martí Colom‐Cadena, Jamie Toombs, Elizabeth M. Simzer…·Tara L. Spires‐Jones

The paper identifies transmembrane protein 97 as a synaptic receptor for amyloid beta in human Alzheimer's disease using advanced microscopy and drug intervention studies.

42 citationstop 1%

humanimaging

𝕏 PostBluesky

NeuroscienceActa NeuropathologicaPeer-reviewedJan 4, 2024

Tau phosphorylated at serine 356 is associated with Alzheimer's disease pathology and can be lowered in mouse and human brain tissue using the NUAK inhibitor WZ4003

Lewis W. Taylor, Elizabeth M. Simzer, Claire Pimblett…·Claire S. Durrant

46 citationstop 1%

humanmouse

𝕏 PostBluesky