Robert I. McGeachan

The paper tests for axon initial segment (AIS) structural plasticity in human, mouse, and rat cortical neurons across different conditions and finds no evidence of AIS length changes over short-term activity modulation.

This study examines amyloid-beta pathology in feline cognitive dysfunction syndrome, finding increased synaptic engulfment by glia in aged and affected cats, mirroring Alzheimer's disease mechanisms.

This study uses live human brain slice cultures to show that physiological and pathological amyloid-beta have opposing effects on synapses, with physiological levels enhancing synaptic transcripts and pathological levels causing synaptic loss.

This study quantifies how GABAB receptor signalling contributes to circuit-level inhibition in rat and human cortical principal cells across the lifespan, revealing age and species differences.

The paper identifies transmembrane protein 97 as a synaptic receptor for amyloid beta in human Alzheimer's disease using advanced microscopy and drug intervention studies.

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.