Author

Hayato Hirai

The University of TokyoORCID 0000-0001-9811-429XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Akinori EndoiD· 1 shared Daichi SadatoiD· 1 shared Hideya KawajiiD· 1 shared Hideyuki YoneiD· 1 shared Hiroko Masuda· 1 shared Hiromitsu KonoiD· 1 shared Hiroshi Shitara· 1 shared Hiroyuki SasanumaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

Akinori EndoORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 21, 2026

BRCA2 loss triggers a downward spiral of genomic instability via ROS-dependent metabolic collapse

Hayato Hirai, Tomohiro Iguchi, Kenji Kitajima…·Hiroyuki Sasanuma

This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.

DOI 10.64898/2026.05.15.725601

humanDNA methylation

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GeneticsScientific ReportsPeer-reviewedOct 5, 2022

Gene mapping methodology powered by induced genome rearrangements

Hideyuki Yone, Hiromitsu Kono, Hayato Hirai, Kunihiro Ohta

This study compares TAQing and conventional mutagenesis to identify genes responsible for flocculation in yeast, finding TAQing narrows down candidate loci more effectively.

4 citations

yeastDNA methylation

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