Jesper Wengel

This paper introduces a method to efficiently synthesize LNA-modified RNAs using a mutant T7 RNA polymerase, demonstrating its utility in SELEX for generating therapeutically relevant aptamers with high affinity and nuclease resistance.

This study shows that anti-gene oligonucleotides targeting GAA*TTC repeats in Friedreichs ataxia increase FXN expression in patient cells.

AptaBERT predicts aptamer binding interactions with proteins and small molecules, achieving high ROC-AUC scores and outperforming existing models.