Author

Negin Mozafari

Karolinska University HospitalORCID 0000-0002-0882-7438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Rula ZainiD· 3 shared Anastasia Rastokina· 2 shared Jorge CebriániD· 2 shared Sergei M. MirkiniD· 2 shared C I Edvard Smith· 1 shared C. I. Edvard Smith· 1 shared Claudia Marina VargiuiD· 1 shared Cristina S. J. RochaiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Rula ZainORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Anti-gene oligonucleotides targeting Friedreichs ataxia expanded GAA:TTC repeats increase Frataxin expression

Negin Mozafari, Salomé Milagres, Tea Umek, Cristina S. J. Rocha, Claudia Marina Vargiu, Fiona Freyberger, Osama Saher, Марек Напиерала, Jill S. Napierala, Pontus Blomberg, Per T. Jørgensen, Tanel Punga, C. I. Edvard Smith, Jesper Wengel, Rula Zain

This study shows that anti-gene oligonucleotides targeting GAA*TTC repeats in Friedreichs ataxia increase FXN expression in patient cells.

Molecular Therapy — Nucleic Acids · Apr 17, 2025Peer-reviewedMolecular Biology

Large-scale expansions and replication stalling of Friedreich's ataxia GAA repeats in an experimental mammalian system

Anastasia Rastokina, Jorge Cebrián, Negin Mozafari, Nicholas H Mandel, C I Edvard Smith, Massimo Lopes, Rula Zain, Sergei M. Mirkin

This study develops an experimental system to analyze GAA repeat expansions and replication fork stalling in human cells, finding that repeat expansions depend on proteins involved in replication fork stalling and restart.

Nucleic Acids Research · May 22, 2023Peer-reviewedGenetics

Large-scale expansions of Friedreich's ataxia GAA·TTC repeats in human cells are prevented by LNA-DNA oligonucleotides and PNA oligomers

Anastasia Rastokina, Negin Mozafari, Jorge Cebrián, Smith Rjh, Sergei M. Mirkin, Rula Zain

This study shows that LNA-DNA and PNA oligomers prevent GAA·TTC repeat expansions in human cells by disrupting triplex DNA structures formed by these repeats.

bioRxiv · Jul 4, 2022 · PreprintGenetics