Julián Valero

This study uses single-particle tracking to compare early entry checkpoints of SARS-CoV-2 G614 and BA.5 variants, revealing variant-specific differences in binding and internalization.

This paper develops DNA-RNA artificial cells with RNA organelles that enable spatially encoded functions and signal processing through aptamer-based protein recruitment and environmental responsiveness.

The paper demonstrates the enzymatic synthesis of chemically modified RNA using a mutant T7 RNA polymerase and evaluates the impact of modifications on transcription efficiency and fidelity.

This paper introduces FY-RNA origami structures that are serum-stable and capable of molecular sensing and targeting, revealing structural insights through cryo-EM and simulations.

This paper introduces a method to efficiently synthesize LNA-modified RNAs using a mutant T7 RNA polymerase, demonstrating its utility in SELEX for generating therapeutically relevant aptamers with high affinity and nuclease resistance.

This study develops a mannosylated nucleic acid-based vaccine platform that targets Langerhans cells in the skin, enhancing antigen presentation and T cell activation.