Author

Kathrine Pedersen

Aarhus UniversityORCID 0000-0002-3058-7960Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Jesper Thagaard WengeliD· 1 shared Jørgen KjemsiD· 1 shared Julián ValeroiD· 1 shared Kevin NeisiD· 1 shared Laia CivitiD· 1 shared Michael SchachtneriD· 1 shared Ralf WagneriD· 1 shared Steffen ThieliD· 1 shared

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Jesper Thagaard WengelORCID

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1 paper

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Molecular BiologySmall StructuresPeer-reviewedMar 1, 2026

Lock, Protect, and Bind: In Vitro Selection of LNA-modified Aptamers Using a Mutant T7 RNA Polymerase

Kevin Neis, Laia Civit, Kathrine Pedersen…·Julián Valero

This paper introduces a method to efficiently synthesize LNA-modified RNAs using a mutant T7 RNA polymerase, demonstrating its utility in SELEX for generating therapeutically relevant aptamers with high affinity and nuclease resistance.

3 citationstop 4%

experimental assay