NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity
Xu Zhang, Roman Vlkolinský, Chongyang Wu…·Stuart A. Lipton
This study shows that S-nitrosylation of CRTC1 impairs CREB-dependent gene expression in Alzheimer's disease models, leading to synaptic dysfunction and suggesting a therapeutic target.