Luka Mesin

Across 119 monoclonal germinal centers, B cell affinity rises reliably despite divergent phylogenies. Selection is noisy but persistent; mutability limits exploration. A DMS-based landscape shows saturating fitness and survivorship biases.

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

The paper investigates how antibodies from an ongoing immune response affect interclonal competition in germinal centers, finding that antibody feedback reduces clones recognizing the same epitopes as circulating antibodies.