Gabriel D. Victora

This study shows eosinophils mediate protective intestinal remodeling in food allergies by interacting with epithelial cells, and their depletion worsens symptoms.

Across 119 monoclonal germinal centers, B cell affinity rises reliably despite divergent phylogenies. Selection is noisy but persistent; mutability limits exploration. A DMS-based landscape shows saturating fitness and survivorship biases.

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

The paper uses simulation-based deep learning to infer the affinity-fitness response function in germinal centers from experimental data.

The paper investigates how antibodies from an ongoing immune response affect interclonal competition in germinal centers, finding that antibody feedback reduces clones recognizing the same epitopes as circulating antibodies.

The paper shows how immune cells adapt to different stem cell niches in skin to maintain tissue homeostasis by adjusting their functions based on the niche's specific demands.

This paper develops a method to generate TCR knock-in mice with functional T cells by integrating TCRβ sequences into the Trb locus using AAV and CRISPR/Cas9, overcoming limitations of traditional transgenic models.

This study compares nucleotide context models and protein language models for predicting antibody affinity maturation, finding nucleotide-based models perform better.

The paper identifies distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation through varied interactions.

This study identifies distinct roles of nucleoside-modified mRNA and lipid nanoparticles in promoting Tfh cell responses through different mechanisms.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.