Jana Bilanovic

This study shows that lymphatic remodeling in skin and lymph nodes constrains germinal center size and function to optimize protective antibody responses during viral infection.

The paper investigates how antibodies from an ongoing immune response affect interclonal competition in germinal centers, finding that antibody feedback reduces clones recognizing the same epitopes as circulating antibodies.

This paper develops a method to generate TCR knock-in mice with functional T cells by integrating TCRβ sequences into the Trb locus using AAV and CRISPR/Cas9, overcoming limitations of traditional transgenic models.