Author

Simon P. Brooks

Cardiff UniversityORCID 0000-0001-9853-6177Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:simulation· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Ilaria MorellaiD· 2 shared Riccardo BrambillaiD· 2 shared Stephen B. DunnettiD· 2 shared Alessandro PapaleiD· 1 shared Anna CavacciniiD· 1 shared Anna Rosa CartaiD· 1 shared Anne Glickenhaus· 1 shared Antonia GurgoneiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

Ilaria MorellaORCID

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3 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedJan 28, 2025

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain

Enrico Bagnoli, Yu‐En Lin, Sophie Burel…·Miratul M. K. Muqit

This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.

21 citationstop 1%

mouseexperimental assay

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NeurosciencebioRxivPreprintDec 21, 2018

Modulation of ERK1/MAPK3 potentiates ERK nuclear signalling, facilitates neuronal cell survival and improves memory in mouse models of neurodegenerative disorders

Marzia Tina Indrigo, Ilaria Morella, Daniel I. Orellana…·Stefania Fasano

This study shows that enhancing ERK2 signalling protects neurons and improves memory in mouse models of neurodegenerative diseases.

2 citations

mouseexperimental assay

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NeuroscienceScientific ReportsPeer-reviewedFeb 8, 2017

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease

Robert M. Bragg, Sydney R. Coffey, Rory M. Weston…·Jeffrey B. Carroll

This study shows that B6.HttQ111/+ mice exhibit early transcriptional and proteostatic deficits before synapse loss and neurodegeneration in HD.

21 citations

mousesimulation

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