GeneticsScientific ReportsPeer-reviewed
In vivo deletion of a GWAS-identified Myb distal enhancer acts on Myb expression, globin switching, and clinical erythroid parameters in beta-thalassemia
Virginie Deleuze, Tharshana Stephen, Mohammad Salma…·Éric Soler
The paper investigates the functional impact of a GWAS-identified Myb enhancer in beta-thalassemia by generating a knock-out mouse model and analyzing its effects on erythropoiesis and clinical parameters.
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