Author

Tharshana Stephen

Bicêtre HospitalORCID 0000-0002-6560-656XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alex MaasiD· 1 shared Ambre Dangien· 1 shared Anne M. FourieiD· 1 shared Barbara Joyce-Shaikh· 1 shared Carrie N. Arnold Greving· 1 shared Cédric Orfeo· 1 shared Charles‐Henri LecellieriD· 1 shared Charlotte Andrieu‐SoleriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Alex MaasORCID

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2 papers

Recent·Most cited

In vivo deletion of a GWAS-identified Myb distal enhancer acts on Myb expression, globin switching, and clinical erythroid parameters in beta-thalassemia

Virginie Deleuze, Tharshana Stephen, Mohammad Salma, Cédric Orfeo, Ruud Jorna, Alex Maas, Vilma Barroca, Marie-Laure Arcangeli, Charles‐Henri Lecellier, Charlotte Andrieu‐Soler, Frank G. Grosveld, Éric Soler

The paper investigates the functional impact of a GWAS-identified Myb enhancer in beta-thalassemia by generating a knock-out mouse model and analyzing its effects on erythropoiesis and clinical parameters.

Scientific Reports · Mar 15, 2025Peer-reviewedGenetics

IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cells

Laetitia Camard, Tharshana Stephen, Hanane Yahia‐Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, , Lars Rogge

This study identifies IL-23's role in shaping the functional plasticity of human MAIT cells, revealing its impact on autoimmunity and cytotoxic functions through AP-1 transcription factors.

iScience · Jan 25, 2025Peer-reviewedImmunology