Frank G. Grosveld

scRIPT is a single-cell lineage-tracing method that improves coverage and reliability in differentiation protocols by integrating rapid barcoding, sorting, and sequencing with quality control.

The paper investigates the roles of Atf3, Zfp711, and Bcl6b in early hemato-endothelial lineage specification using scRNA-seq and KO mESCs, finding distinct effects on mesodermal and hematopoietic lineages.

The paper investigates the functional impact of a GWAS-identified Myb enhancer in beta-thalassemia by generating a knock-out mouse model and analyzing its effects on erythropoiesis and clinical parameters.

The paper identifies a novel XACT lncRNA transcript expressed in both active and inactive X chromosomes, with roles in erythroid differentiation and AML subtypes beyond its role in XCI.

This study identifies Fc-dependent protective antibodies against influenza A virus neuraminidase, showing that epitope availability and Fc-mediated effector functions influence their efficacy.

The paper investigates the cis-regulatory landscape of DACT2 and SMOC2 in developing synovial joints using chromatin capture and enhancer assays.

The paper investigates the effects of the Klf1 Nan variant on erythroid maturation, finding that it causes nuclear condensation defects and deregulates Xpo7 expression.

This paper describes the 3D chromatin architecture of human and mouse genomes at multiple scales, showing its dynamic organization and co-evolution with DNA sequence.