Author

Jennifer Yon-Li Wo

Massachusetts General HospitalORCID 0000-0001-9872-5912Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Hannah I. HoffmaniD· 3 shared Jimmy A. GuoiD· 3 shared Mari A. Mino-KenudsoniD· 3 shared Theodore Sunki HongiD· 3 shared William L. HwangiD· 3 shared Carina ShiauiD· 2 shared Carlos F. Fernandez-del CastilloiD· 2 shared Cristina Rosa FerroneiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Hannah I. HoffmanORCID

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3 papers

Recent·Most cited

Cancer BiologyClinical Cancer ResearchPeer-reviewedMar 18, 2026

Distinct malignant cell states and myeloid glutamate signaling associated with aggressive pancreatic neuroendocrine tumors

Jeanna M. Qiu, Jae Won Cho, Phuong Trang Nguyen…·William L. Hwang

This study identifies distinct malignant cell states and myeloid glutamate signaling in aggressive pancreatic neuroendocrine tumors, linking them to poor clinical outcomes and therapeutic vulnerabilities.

1 citation

humanscRNA-seq

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Cancer BiologybioRxivPreprintAug 26, 2025

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer

Peter L. Wang, Nicole A. Lester, Ella N. Perrault…·William L. Hwang

This study identifies Pdgfd-Pdgfrb signaling as a driver of perineural invasion in pancreatic cancer by promoting cancer cell invasiveness and nerve engagement.

DOI 10.1101/2025.08.26.672505

humanbulk RNA-seq

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GenomicsbioRxivPreprintAug 25, 2020

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo…·Aviv Regev

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.

33 citations

humansnRNA-seq

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