Author

Carlos F. Fernandez-del Castillo

Massachusetts General HospitalORCID 0000-0001-5975-7225Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Cristina Rosa FerroneiD· 2 shared Hannah I. HoffmaniD· 2 shared Jennifer Yon-Li WoiD· 2 shared Jimmy A. GuoiD· 2 shared Mari A. Mino-KenudsoniD· 2 shared Theodore Sunki HongiD· 2 shared William L. HwangiD· 2 shared Alexander M. TsankoviD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Cristina Rosa FerroneORCID

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2 papers

Recent·Most cited

Distinct malignant cell states and myeloid glutamate signaling associated with aggressive pancreatic neuroendocrine tumors

Jeanna M. Qiu, Jae Won Cho, Phuong Trang Nguyen, Nicole A. Lester, Jennifer Su, Jimmy A. Guo, Hannah I. Hoffman, Carina Shiau, Nicholas J Caldwell, Shugo Muratani, Miranda Galvan, Jessica E. Proctor, Zackery A. Ely, Steven Wang, Maria L. Ganci, , William L. Hwang

This study identifies distinct malignant cell states and myeloid glutamate signaling in aggressive pancreatic neuroendocrine tumors, linking them to poor clinical outcomes and therapeutic vulnerabilities.

Clinical Cancer Research · Mar 18, 2026Peer-reviewedCancer Biology

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Rahul R. Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Jason Reeves, Daniel R. Zollinger, George M. Eng, Jason M. Schenkel, , Aviv Regev

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.

bioRxiv · Aug 25, 2020 · PreprintGenomics