Fabian V. Filipp

This study identifies the MCUR1-CCDC90B complex as a mitochondrial scaffold regulating metabolic homeostasis, showing its role in amino acid metabolism and linking its deficiency to neurometabolic disease.

The paper identifies a network of epigenomic and transcriptional cooperation involving master regulators in cancer, revealing their roles in gene regulation and therapeutic targeting.

The paper establishes an in vitro model of MAPK inhibitor resistance in melanoma and identifies transcriptional changes and pathways involved in resistance mechanisms.

This study identifies BCL2 hyperactivity's role in enhancing glutaminolytic flux and mitochondrial metabolism in lymphoma, revealing metabolic dependencies as therapeutic targets.