John L. Muschler

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

This study shows HBP1 protects against acute pancreatitis but promotes pancreatic cancer progression in the presence of KRAS mutations.

The paper introduces a deep learning tool for automated histologic feature quantification in murine pancreatic disease models, showing high correlation with immunostaining results and accurate differentiation of disease states.