Author

Vidhi M. Shah

Oregon Health & Science UniversityORCID 0000-0001-7934-978XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Rosalie C. SearsiD· 4 shared Colin J. DanieliD· 3 shared Dove J. Keith· 3 shared Jonathan Robert BrodyiD· 3 shared Koei ChiniD· 3 shared Alexander SmithiD· 2 shared Alexandra Q. BartlettiD· 2 shared Aubry Matter· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Rosalie C. SearsORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 15, 2025

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway

Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel…·Rosalie C. Sears

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

DOI 10.64898/2025.12.12.693851

humanbulk RNA-seq

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Cancer BiologyJournal for ImmunoTherapy of CancerPeer-reviewedNov 1, 2025

Post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma

Yifei Guo, Jennifer M. Finan, Alexandra Q. Bartlett…·Robert L Eil

This study shows that HuR promotes immune evasion in PDAC by inhibiting T cell infiltration and function, suggesting HuR as a therapeutic target with immunotherapy.

DOI 10.1158/2326-6066.cir-26-0472

mousebulk RNA-seq

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Cell BiologybioRxivPreprintMay 13, 2025

PIN1 Drives Cellular Plasticity and Immune Modulation in Chronic Pancreatitis

Vidhi M. Shah, Alexandra Q. Bartlett, Canping Chen…·Rosalie C. Sears

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

DOI 10.1101/2025.05.13.653850

mousebulk RNA-seq

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Cell BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2025

HMG Box-Containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression.

Seung-Won Lee, Taelor J. Ekstrom, Elise C. Manalo…·Jungsun Kim

This study shows HBP1 protects against acute pancreatitis but promotes pancreatic cancer progression in the presence of KRAS mutations.

1 citation

mousehuman

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